Which type of substance would face difficulty to pass through the cell membrane?

Which type of substance would face difficulty to pass through the cell membrane?
  1. Substance with hydrophobic moiety
  2. Substance with hydrophilic moiety
  3. All substance irrespective of hydrophobic and hydrophilic moiety
  4. Substance soluble in lipids

Solution

As plasma membrane is made up to phospholipid, it only allow free transfer of Fat soluble substances (Hydrophobic) it does not allow Hydrophilic substance to pass from it.

Asked in: NEET 2022 (Phase 2)

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