Thalassemia and sickle cell anaemia are caused due to a problem in globin molecule synthesis. Select the…

Thalassemia and sickle cell anaemia are caused due to a problem in globin molecule synthesis. Select the correct statement.
  1. Both are due to a qualitative defect in globin chain synthesis
  2. Both are due to a quantitative defect in globin chain synthesis
  3. Thalassemia is due to less synthesis of globin molecules
  4. Sickle cell anemia is due to a quantitative problem of globin molecules

Solution

Thalassemia differs from sickle-cell anaemia in that the former is a quantitative problem of synthesizing too few globin molecules while the latter is a qualitative problem of synthesizing an incorrectly functioning globin.

Asked in: NEET 2017

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