Sickle cell anaemia is

Sickle cell anaemia is
  1. an autosomal linked dominant trait
  2. caused by substitution of valine by glutamic acid in the $\beta$-globin chain of haemoglobin
  3. caused by a change in base pair of DNA
  4. characterized by elongated sickle like $\mathrm{RBC}$ with a nucleus

Solution

Sickle-cell anaemia is caused by a change in a single base pair of DNA. It is a genetic disease reported from negroes. The individuals of sickle-cell anaemia are immune to malaria.

Asked in: NEET 2009 (Screening)

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