Characterized by elongated sickle like RBCs with a nucleus
An autosomal linked dominant trait
Caused by substitute of valine by glutamic acid in the beta globin chain of haemoglobin
Caused by a change in a single base pair of DNA
Solution
Sickle cell anemia is caused by a point mutation in the beta-globin gene of hemoglobin. Specifically, a single base pair substitution in the DNA changes the codon from glutamic acid to valine at the sixth position of the beta-globin protein. This change causes the hemoglobin molecules to aggregate, leading to the characteristic sickle-shaped red blood cells.