In which one of the following enzymes, is copper necessarily associated as an activator?
In which one of the following enzymes, is copper necessarily associated as an activator?
carbonic anhydrase
tryptophanase
lactic dehydrogenase
tyrosinase.
Solution
The structure of tyrosinase can be divided into three domains: the central domain, the N-terminal domain, and the $\mathrm{C}$-terminal domain. The central domain, which is composed of six conserved histidine residues, contains the $\mathrm{CuA}$ and $\mathrm{CuB}$ oxidizing ions.
Related Theory
Tyrosinase is involved in the biosynthesis of melanin in the melanosomes causing pigmentation of skin, hair and eyes in mammals providing the protection against UV. It converts a protein building block (amino acid) called tyrosine to another compound called dopaquinone.