In which of the following, ortho/para substitution by an electrophile is very facile?

In which of the following, ortho/para substitution by an electrophile is very facile?
  1. Nitrobenzene
  2. Phenol
  3. Benzoic acid
  4. Acetophenone

Solution

- OH group is ortho/para directing and makes the benzene ring more active towards electrophilic substitution. Thus, ortho/para substitution in phenol by an electrophile is very facile.

Asked in: AP EAMCET 2010

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