In which disorder change of single base pair in the gene for beta globin chain results in change of glutamic…
In which disorder change of single base pair in the gene for beta globin chain results in change of glutamic acid to valine?
Haemophilia
Phenylketonuria
Thalassemia
Sickle cell anaemia
Solution
Sickle-cell anaemia is caused by mutation of the gene controlling $\beta$-chain of haemoglobin. Due to this mutation, glutamic acid present at $6^{\text {th }}$ position of the $\beta$-chain is replaced by amino acid valine.