In osazone formation, glucose reacts with three molecules of phenylhydrazine. Which statement is true…
In osazone formation, glucose reacts with three molecules of phenylhydrazine. Which statement is true regarding this?
All the three molecules react in similar fashion
Two molecules react in similar manner, while the third reacts in different way
All the three molecules react in different ways
None of the above is true
Solution
First molecule of phenylhydrazine unedrgoes nucleophilic addition on carbonyl (- CHO in glucose and $>\mathrm{CO}$ in fructose) group. Second molecule of the reagent oxidizes $-\mathrm{CHOH}$ - at position 2 (in aldoses) or $-\mathrm{CH}_{2} \mathrm{OH}$ at position 1 (in ketoses) to form $-\mathrm{CHO}$ or $>\mathrm{C}=\mathrm{O}$ respectively. The third molecule again undergoes nucleophilic addition on the newly developed carbonyl group to form osazone.
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