Haemophilia is more commonly seen in human males than in human females because:

Haemophilia is more commonly seen in human males than in human females because:
  1. a greater proportion of girls die in infancy
  2. this disease is due to a Y-linked recessive mutation
  3. this disease is due to an X-linked recessive mutation
  4. this disease is due to an X-linked dominant mutation.

Solution

Haemophilia being a sex chromosome related recessive disorder has its gene present on $\mathrm{X}$ chromosome. Since males have one $\mathrm{X}$ and one $\mathrm{Y}$ chromosome, and the genes present on $\mathrm{X}$ don't have counter genes on $\mathrm{Y}$, only one affected gene (to be present on $\mathrm{X}$ ) is required for the disease in males. While in females, there are $2 \mathrm{X}$ chromosomes. For the disease to occur both the $\mathrm{X}$ chromosomes should have the affected genes which is a rare chance. For this to be possible, the father of the female must be diseased while the mother must atleast be a carrier.

Asked in: NEET 2005

Practice more Principles of Inheritance and Variation questions on Aicharya