Anaphase promoting complex (APC) is a protein degradation machinery necessary for proper mitosis of animal…

Anaphase promoting complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cells. If APC is defective in a human cell, which of the following is expected to occur?
  1. Chromosomes will not condense
  2. Chromosomes will be fragmented
  3. Chromosomes will not segregate
  4. Recombination of chromosome arms will occur

Solution

Anaphase Promoting Complex (APC) is a protein necessary for the separation of daughter chromosomes during anaphase.

APC degenerates proteins binding the two chromatids in the region of the centromere. As a result, the centromere of each chromosome divides.

If APC is defective, then the chromosomes will fail to segregate during anaphase.

Asked in: NEET 2017

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