A person suffering from a disease caused by Plasmodium, experiences recurring chill and fever at the time…

A person suffering from a disease caused by Plasmodium, experiences recurring chill and fever at the time when the
  1. sporozoites released from $\mathrm{RBCs}$ are being rapidly killed and broken down inside spleen
  2. trophozoites reach maximum growth and give out certain toxins
  3. parasite after its rapid multiplication inside RBCs ruptures them, releasing the stage to enter fresh RBCs
  4. microgametcytes and megagametocytes are being destroyed by the WBCs

Solution

In malaria, chill and fever is due to the release of a toxic substance haemozoin, formed by breakdown of haemoglobin present in RBCs. It will be released after the rupture of RBCs in erythrocytic schizogony.

Asked in: NEET 2010 (Mains)

Practice more Human Health and Diseases questions on Aicharya